Objective: To study the distribution and drug resistance of pathogenic bacteria detected from hepatobiliary surgery during the past two years in our hospital.
Methods: Retrospective study on the distribution, category and drug resistance of pathogenic bacteria in patients of hepatobiliary surgery from 2008 to 2009.
Results: A total of 594 pathogenic bacteria were isolated. Among them 418 isolates(70.4%)were Gram negative bacteria, 142 isolates(23.9%)were Gram positive bacteria, and 34 isolates(5.7%)were fungi. The most common Gram negative bacteria was Escherichia coli (19.8%of the isolates) and The dominant Gram positive pathogenic bacteria was Enterococcus faecium. Almost all of the Gram negative pathogenic bacteria were sensitive to carbapenum. ESBLs producing strains were more resistant to penicillins and cephalosprins than ESBLs non producing strains. Staphylococcus was sensitive to vancomycin and linezolid. The drug resistance of meticillin-resistant Staphylococcus (MRS) were higher to commonly used antibiotics than meticillin-sensitive Streptococcus (MSS). Vancomycin and linezolid remain lower drug-resistance rates to Enterococcus sp.
Conclusions: The most pathogenic bacteria isolated from hepatobiliary surgery are Gram-negative bacteria. It is necessary to monitoring the pathogen to guiding selection of antibiotics based on drug sensitive tests.